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Article

Dicer recognizes the 5' end of RNA for efficient and accurate processing.

Nature - 13 Jul 2011

Park Jong-Eun, Heo Inha, Tian Yuan, Simanshu Dhirendra K, Chang Hyeshik, Jee David, Patel Dinshaw J, Kim V Narry

Abstract excerpt

A hallmark of RNA silencing is a class of approximately 22-nucleotide RNAs that are processed from double-stranded RNA precursors by Dicer. Accurate processing by Dicer is crucial for the functionality of microRNAs (miRNAs). The current model posits that Dicer selects cleavage sites by measuring a set distance from the 3' overhang of the double-stranded RNA terminus. Here we report that human Dicer anchors not...

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PMID: 21753850
DOI: 10.1038/nature10198
PMCID: PMC4693635

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