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Article

Structural and functional insights into the fly microRNA biogenesis factor Loquacious.

RNA (New York, N.Y.) - 1 Mar 2016

Jakob Leonhard, Treiber Thomas, Treiber Nora, Gust Alexander, Kramm Kevin, Hansen Kerrin, Stotz Mathias, Wankerl Ludwig, Herzog Franz, Hannus Stefan, Grohmann Dina, Meister Gunter

Abstract excerpt

In the microRNA (miRNA) pathway, Dicer processes precursors to mature miRNAs. For efficient processing, double-stranded RNA-binding proteins support Dicer proteins. In flies, Loquacious (Loqs) interacts with Dicer1 (dmDcr1) to facilitate miRNA processing. Here, we have solved the structure of the third double-stranded RNA-binding domain (dsRBD) of Loqs and define specific structural elements that interact with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26769856
DOI: 10.1261/rna.055426.115
PMCID: PMC4748816

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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