Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional Interaction between HEXIM and Hedgehog Signaling during Drosophila Wing Development.

PloS one - 1 Jan 2016

Nguyen Duy, Fayol Olivier, Buisine Nicolas, Lecorre Pierrette, Uguen Patricia

Abstract excerpt

Studying the dynamic of gene regulatory networks is essential in order to understand the specific signals and factors that govern cell proliferation and differentiation during development. This also has direct implication in human health and cancer biology. The general transcriptional elongation regulator P-TEFb regulates the transcriptional status of many developmental genes. Its biological activity is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Checkpoints
Share to Cell Death
Share to Gene Knockdown Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hedgehog Proteins

Share to Organogenesis

Share to RNA-Binding Proteins

Share to RNA Interference

Share to Wings, Animal

Source

Open in PubMed Open full text

Identifiers

PMID: 27176767
DOI: 10.1371/journal.pone.0155438
PMCID: PMC4866710

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional Interaction between HEXIM and Hedgehog Signaling during Drosophila Wing Development.PMID 27176767Read ↗

Oligomerization of HEXIM1 via 7SK snRNA and coiled-coil region directs the inhibition of P-TEFb.Semantic proximity Read ↗

Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor.Semantic proximity Read ↗

A conserved function of the chromatin ATPase Kismet in the regulation of hedgehog expression.Semantic proximity Read ↗

Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling.Semantic proximity Read ↗

Hyperplastic discs differentially regulates the transcriptional outputs of hedgehog signaling.Semantic proximity Read ↗

A human immunodeficiency virus type 1 Tat-like arginine-rich RNA-binding domain is essential for HEXIM1 to inhibit RNA polymerase II transcription through 7SK snRNA-mediated inactivation of P-TEFb.Semantic proximity Read ↗

The Homothorax homeoprotein activates the nuclear localization of another homeoprotein, extradenticle, and suppresses eye development in Drosophila.Semantic proximity Read ↗

Distinct functions of homeodomain-containing and homeodomain-less isoforms encoded by homothorax.Semantic proximity Read ↗

Inhibition of the nuclear import of cubitus interruptus by roadkill in the presence of strong hedgehog signal.Semantic proximity Read ↗

The Hox transcription factor Ubx ensures somatic myogenesis by suppressing the mesodermal master regulator TwistSemantic proximity Read ↗

Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator.Semantic proximity Read ↗

Genetic evidence for the transcriptional-activating function of Homothorax during adult fly development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.