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Article

Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor.

The EMBO journal - 7 Jul 2004

Michels Annemieke A, Fraldi Alessandro, Li Qintong, Adamson Todd E, Bonnet François, Nguyen Van Trung, Sedore Stanley C, Price Jason P, Price David H, Lania Luigi, Bensaude Olivier

Abstract excerpt

The positive transcription elongation factor b (P-TEFb) plays a pivotal role in productive elongation of nascent RNA molecules by RNA polymerase II. Core active P-TEFb is composed of CDK9 and cyclin T. In addition, mammalian cell extracts contain an inactive P-TEFb complex composed of four compon...

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Source

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Identifiers

PMID: 15201869
DOI: 10.1038/sj.emboj.7600275
PMCID: PMC449783

Genes

HEXIM1
CDK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15201869-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor.PMID 15201869Read ↗

A human immunodeficiency virus type 1 Tat-like arginine-rich RNA-binding domain is essential for HEXIM1 to inhibit RNA polymerase II transcription through 7SK snRNA-mediated inactivation of P-TEFb.Semantic proximity Read ↗

Oligomerization of HEXIM1 via 7SK snRNA and coiled-coil region directs the inhibition of P-TEFb.Semantic proximity Read ↗

Phosphorylation of HEXIM1 at Tyr271 and Tyr274 Promotes Release of P-TEFb from the 7SK snRNP Complex and Enhances Proviral HIV Gene Expression.Semantic proximity Read ↗

RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP.Semantic proximity Read ↗

Phosphorylated positive transcription elongation factor b (P-TEFb) is tagged for inhibition through association with 7SK snRNA.Semantic proximity Read ↗

U30 of 7SK RNA forms a specific photo-cross-link with Hexim1 in the context of both a minimal RNA-binding site and a fully reconstituted 7SK/Hexim1/P-TEFb ribonucleoprotein complex.Semantic proximity Read ↗

Structure of the Cyclin T binding domain of Hexim1 and molecular basis for its recognition of P-TEFb.Semantic proximity Read ↗

Catalytic activity of the Bin3/MEPCE methyltransferase domain is dispensable for 7SK snRNP function in <i>Drosophila melanogaster</i>Semantic proximity Read ↗

The crystal structure of the 5΄ functional domain of the transcription riboregulator 7SK.Semantic proximity Read ↗

Transition step during assembly of HIV Tat:P-TEFb transcription complexes and transfer to TAR RNA.Semantic proximity Read ↗

Structure of a Cytoplasmic 11-Subunit RNA Exosome Complex.Semantic proximity Read ↗

7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development.Semantic proximity Read ↗

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