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Article

The Homothorax homeoprotein activates the nuclear localization of another homeoprotein, extradenticle, and suppresses eye development in Drosophila.

Genes & development - 1 Feb 1998

Pai C Y, Kuo T S, Jaw T J, Kurant E, Chen C T, Bessarab D A, Salzberg A, Sun Y H

Abstract excerpt

The Extradenticle (Exd) protein in Drosophila acts as a cofactor to homeotic proteins. Its nuclear localization is regulated. We report the cloning of the Drosophila homothorax (hth) gene, a homolog of the mouse Meis1 proto-oncogene that has a homeobox related to that of exd. Comparison with Meis1 finds two regions of high homology: a novel MH domain and the homeodomain. In imaginal discs, hth expression...

Topics

Amino Acid Sequence
Animals
Cell Nucleus
Cloning, Molecular
DNA-Binding Proteins
Drosophila
Drosophila Proteins
Eye
Gene Expression
Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Insect

Homeodomain Proteins

Molecular Sequence Data

Mutation

Myeloid Ecotropic Viral Integration Site 1 Protein

Neoplasm Proteins

Phenotype

Sequence Alignment

Source

Open in PubMed Open full text

Identifiers

PMID: 9450936
DOI: 10.1101/gad.12.3.435
PMCID: PMC316489

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-9450936-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The Homothorax homeoprotein activates the nuclear localization of another homeoprotein, extradenticle, and suppresses eye development in Drosophila.PMID 9450936Read ↗

Mutational analysis of the Drosophila homothorax gene.Semantic proximity Read ↗

Distinct functions of homeodomain-containing and homeodomain-less isoforms encoded by homothorax.Semantic proximity Read ↗

Dorsotonals/homothorax, the Drosophila homologue of meis1, interacts with extradenticle in patterning of the embryonic PNS.Semantic proximity Read ↗

Genetic evidence for the transcriptional-activating function of Homothorax during adult fly development.Semantic proximity Read ↗

Engrailed cooperates with extradenticle and homothorax to repress target genes in Drosophila.Semantic proximity Read ↗

Opposing interactions between homothorax and Lobe define the ventral eye margin of Drosophila eye.Semantic proximity Read ↗

TALE-class homeodomain transcription factors, homothorax and extradenticle, control dendritic and axonal targeting of olfactory projection neurons in the Drosophila brain.Semantic proximity Read ↗

Control of Drosophila adult pattern by extradenticle.Semantic proximity Read ↗

extradenticle determines segmental identities throughout Drosophila development.Semantic proximity Read ↗

Patterning defects in the primary axonal scaffolds caused by the mutations of the extradenticle and homothorax genes in the embryonic Drosophila brain.Semantic proximity Read ↗

Zebrafish Meis functions to stabilize Pbx proteins and regulate hindbrain patterning.Semantic proximity Read ↗

A model for extradenticle function as a switch that changes HOX proteins from repressors to activators.Semantic proximity Read ↗

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