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Article

Distinct functions of homeodomain-containing and homeodomain-less isoforms encoded by homothorax.

Genes & development - 15 Jun 2006

Noro Barbara, Culi Joaquim, McKay Daniel J, Zhang Wen, Mann Richard S

Abstract excerpt

The homothorax (hth) gene of Drosophila melanogaster is required for executing Hox functions, for head development, and for forming the proximodistal (PD) axis of the appendages. We show that alternative splicing of hth generates two types of protein isoforms, one that contains a DNA-binding homeodomain (HthFL) and one that does not contain a homeodomain (HDless). Both types of Hth isoforms include the...

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Identifiers

PMID: 16778079
DOI: 10.1101/gad.1412606
PMCID: PMC1482483

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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