Article
Distinct functions of homeodomain-containing and homeodomain-less isoforms encoded by homothorax.
Genes & development - 15 Jun 2006
Noro Barbara, Culi Joaquim, McKay Daniel J, Zhang Wen, Mann Richard S
Abstract excerpt
The homothorax (hth) gene of Drosophila melanogaster is required for executing Hox functions, for head development, and for forming the proximodistal (PD) axis of the appendages. We show that alternative splicing of hth generates two types of protein isoforms, one that contains a DNA-binding home...
Topics
- Alleles
- Alternative Splicing
- Amino Acid Sequence
- Animal Structures
- Animals
- Body Patterning
- DNA
- Drosophila Proteins
- Drosophila melanogaster
- Embryo, Nonmammalian
- Gene Expression Regulation, Developmental
- Head
- Homeodomain Proteins
- Mice
- Molecular Sequence Data
- Phenotype
- Protein Binding
- Protein Isoforms