Article
A human immunodeficiency virus type 1 Tat-like arginine-rich RNA-binding domain is essential for HEXIM1 to inhibit RNA polymerase II transcription through 7SK snRNA-mediated inactivation of P-TEFb.
Molecular and cellular biology - 1 Jun 2004
Yik Jasper H N, Chen Ruichuan, Pezda Andrea C, Samford Craig S, Zhou Qiang
Abstract excerpt
The HEXIM1 protein inhibits the kinase activity of P-TEFb (CDK9/cyclin T) to suppress RNA polymerase II transcriptional elongation in a process that specifically requires the 7SK snRNA, which mediates the interaction of HEXIM1 with P-TEFb. In an attempt to define the sequence requirements for HEXIM1 to interact with 7SK and inactivate P-TEFb, we have identified the first 18 amino acids within the previously...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.