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Article

Inhibition of the nuclear import of cubitus interruptus by roadkill in the presence of strong hedgehog signal.

PloS one - 15 Dec 2010

Seong Ki-Hyeon, Akimaru Hiroshi, Dai Ping, Nomura Teruaki, Okada Masahiro, Ishii Shunsuke

Abstract excerpt

Hedgehog (Hh) signalling plays an important role in various developmental processes by activating the Cubitus interruptus (Ci)/Glioblastoma (Gli) family of transcription factors. In the process of proper pattern formation, Ci activity is regulated by multiple mechanisms, including processing, trafficking, and degradation. However, it remains elusive how Ci distinctly recognizes the strong and moderate Hh signals....

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Source

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Identifiers

PMID: 21179535
DOI: 10.1371/journal.pone.0015365
PMCID: PMC3002282

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inhibition of the nuclear import of cubitus interruptus by roadkill in the presence of strong hedgehog signal.PMID 21179535Read ↗

Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus.Semantic proximity Read ↗

The Kto-Skd complex can regulate ptc expression by interacting with Cubitus interruptus (Ci) in the Hedgehog signaling pathway.Semantic proximity Read ↗

Genetic dissection of the Drosophila Cubitus interruptus signaling complex.Semantic proximity Read ↗

A hedgehog-responsive region in the Drosophila wing disc is defined by debra-mediated ubiquitination and lysosomal degradation of Ci.Semantic proximity Read ↗

Dispatched mediates Hedgehog basolateral release to form the long-range morphogenetic gradient in the Drosophila wing disk epithelium.Semantic proximity Read ↗

Ci: a complex transducer of the hedgehog signal.Semantic proximity Read ↗

Nkd1 functions downstream of Axin2 to attenuate Wnt signaling.Semantic proximity Read ↗

Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus.Semantic proximity Read ↗

Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator.Semantic proximity Read ↗

Cubitus interruptus acts to specify naked cuticle in the trunk of Drosophila embryos.Semantic proximity Read ↗

Drosophila hedgehog can act as a morphogen in the absence of regulated Ci processing.Semantic proximity Read ↗

A gain-of-function screen for genes that influence axon guidance identifies the NF-kappaB protein dorsal and reveals a requirement for the kinase Pelle in Drosophila photoreceptor axon targeting.Semantic proximity Read ↗

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