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Article

Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator.

Nature - 1 Jan 2000

Ohlmeyer J T, Kalderon D

Abstract excerpt

In Drosophila, signalling by the protein Hedgehog (Hh) alters the activity of the transcription factor Cubitus interruptus (Ci) by inhibiting the proteolysis of full-length Ci (Ci-155) to its shortened Ci-75 form. Ci-75 is found largely in the nucleus and is thought to be a transcriptional repres...

Topics

Animals
Cell Cycle Proteins
Cyclic AMP-Dependent Protein Kinases
DNA-Binding Proteins
Drosophila
Drosophila Proteins
Hedgehog Proteins
Insect Proteins
Membrane Proteins
Mutation
Protein Serine-Threonine Kinases
Receptors, Cell Surface

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Repressor Proteins

Signal Transduction

Transcription Factors

Ubiquitin-Protein Ligases

Source

Identifiers

PMID: 9874371
DOI: 10.1038/25533

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9874371-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator.PMID 9874371Read ↗

Genetic evidence for a protein kinase A/cubitus interruptus complex that facilitates processing of cubitus interruptus in Drosophila.Semantic proximity Read ↗

Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1.Semantic proximity Read ↗

Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus.Semantic proximity Read ↗

Genetic dissection of the Drosophila Cubitus interruptus signaling complex.Semantic proximity Read ↗

Drosophila hedgehog can act as a morphogen in the absence of regulated Ci processing.Semantic proximity Read ↗

Ci: a complex transducer of the hedgehog signal.Semantic proximity Read ↗

Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus.Semantic proximity Read ↗

Modulation of the Suppressor of fused protein regulates the Hedgehog signaling pathway in Drosophila embryo and imaginal discs.Semantic proximity Read ↗

Inhibition of the nuclear import of cubitus interruptus by roadkill in the presence of strong hedgehog signal.Semantic proximity Read ↗

Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus.Semantic proximity Read ↗

Hyperplastic discs differentially regulates the transcriptional outputs of hedgehog signaling.Semantic proximity Read ↗

The fused protein kinase regulates Hedgehog-stimulated transcriptional activation in Drosophila Schneider 2 cells.Semantic proximity Read ↗

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