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Article

Oligomerization of HEXIM1 via 7SK snRNA and coiled-coil region directs the inhibition of P-TEFb.

Nucleic acids research - 1 Jan 2005

Blazek Dalibor, Barboric Matjaz, Kohoutek Jiri, Oven Irena, Peterlin B Matija

Abstract excerpt

Transcriptional elongation of most eukaryotic genes by RNA polymerase II requires the kinase activity of the positive transcription elongation factor b (P-TEFb). The catalytically active P-TEFb complex becomes inactive when sequestered into the large complex by the cooperative actions of 7SK snRN...

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Source

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Identifiers

PMID: 16377779
DOI: 10.1093/nar/gki997
PMCID: PMC1322273

Genes

HEXIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16377779-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oligomerization of HEXIM1 via 7SK snRNA and coiled-coil region directs the inhibition of P-TEFb.PMID 16377779Read ↗

Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor.Semantic proximity Read ↗

A human immunodeficiency virus type 1 Tat-like arginine-rich RNA-binding domain is essential for HEXIM1 to inhibit RNA polymerase II transcription through 7SK snRNA-mediated inactivation of P-TEFb.Semantic proximity Read ↗

Phosphorylation of HEXIM1 at Tyr271 and Tyr274 Promotes Release of P-TEFb from the 7SK snRNP Complex and Enhances Proviral HIV Gene Expression.Semantic proximity Read ↗

RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP.Semantic proximity Read ↗

Phosphorylated positive transcription elongation factor b (P-TEFb) is tagged for inhibition through association with 7SK snRNA.Semantic proximity Read ↗

Structure of the Cyclin T binding domain of Hexim1 and molecular basis for its recognition of P-TEFb.Semantic proximity Read ↗

7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development.Semantic proximity Read ↗

U30 of 7SK RNA forms a specific photo-cross-link with Hexim1 in the context of both a minimal RNA-binding site and a fully reconstituted 7SK/Hexim1/P-TEFb ribonucleoprotein complex.Semantic proximity Read ↗

Functional Interaction between HEXIM and Hedgehog Signaling during Drosophila Wing Development.Semantic proximity Read ↗

HEXIM1/P-TEFb complex controls RNA polymerase II pause release and immediate early gene induction following neuronal depolarizationSemantic proximity Read ↗

The N-terminal domains of FLASH and Lsm11 form a 2:1 heterotrimer for histone pre-mRNA 3'-end processing.Semantic proximity Read ↗

The Coxiella burnetii T4SS effector protein AnkG hijacks the 7SK small nuclear ribonucleoprotein complex for reprogramming host cell transcription.Semantic proximity Read ↗

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