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Article

Hyperplastic discs differentially regulates the transcriptional outputs of hedgehog signaling.

Mechanisms of development - 1 Aug 2014

Wang Guolun, Tang Xiaofang, Chen Yujie, Cao Jun, Huang Qinzhu, Ling Xuemei, Ren Wenyan, Liu Songqing, Wu Yihui, Ray Lorraine, Lin Xinhua

Abstract excerpt

Hedgehog (Hh) acts as a morphogen to activate the transcription of diverse target genes via its downstream effector Cubitus interruptus (Ci). Currently, it is less understood how Ci recruits co-factors to activate transcription. Here we report that hyperplastic discs (hyd), an E3 ubiquitin ligase, can differentially regulate the transcriptional outputs of Hh signaling. We show that loss of Hyd activity caused...

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Identifiers

PMID: 24854243
DOI: 10.1016/j.mod.2014.05.002
PMCID: PMC4351657

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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