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Article

Determining the association between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and genomic DNA methylation level: A meta-analysis.

Birth defects research. Part A, Clinical and molecular teratology - 1 Aug 2016

Wang Li, Shangguan Shaofang, Chang Shaoyan, Yu Xin, Wang Zhen, Lu Xiaolin, Wu Lihua, Zhang Ting

Abstract excerpt

BACKGROUND: The methylenetetrahydrofolate reductase (MTHFR) polymorphism is a risk factor for neural tube defects. C677T and A1298C MTHFR polymorphisms produce an enzyme with reduced folate-related one carbon metabolism, and this has been associated with aberrant methylation modifications in DNA and protein. METHODS: A meta-analysis was conducted to assess the association between MTHFR C677T/A1298C genotypes and...

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Source

Identifiers

PMID: 27173682
DOI: 10.1002/bdra.23511

Genes

MTHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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