Article
Determining the association between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and genomic DNA methylation level: A meta-analysis.
Birth defects research. Part A, Clinical and molecular teratology - 1 Aug 2016
Wang Li, Shangguan Shaofang, Chang Shaoyan, Yu Xin, Wang Zhen, Lu Xiaolin, Wu Lihua, Zhang Ting
Abstract excerpt
BACKGROUND: The methylenetetrahydrofolate reductase (MTHFR) polymorphism is a risk factor for neural tube defects. C677T and A1298C MTHFR polymorphisms produce an enzyme with reduced folate-related one carbon metabolism, and this has been associated with aberrant methylation modifications in DNA...
Topics
- DNA Methylation
- Female
- Gene Expression
- Genotype
- Humans
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
- Neural Tube Defects
- Odds Ratio
- Polymorphism, Single Nucleotide
- Risk Factors