Article
Assessing the association between the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism and blood folate concentrations: a systematic review and meta-analysis of trials and observational studies.
The American journal of clinical nutrition - 1 Jun 2015
Tsang Becky L, Devine Owen J, Cordero Amy M, Marchetta Claire M, Mulinare Joseph, Mersereau Patricia, Guo Jing, Qi Yan Ping, Berry Robert J, Rosenthal Jorge, Crider Krista S, Hamner Heather C
Abstract excerpt
BACKGROUND: The methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism is a risk factor for neural tube defects. The T allele produces an enzyme with reduced folate-processing capacity, which has been associated with lower blood folate concentrations. OBJECTIVE: We assessed the association between MTHFR C677T genotypes and blood folate concentrations among healthy women aged 12-49 y. DESIGN: We conducted...
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