Article
Global DNA hypomethylation is associated with NTD-affected pregnancy: A case-control study.
Birth defects research. Part A, Clinical and molecular teratology - 1 Jul 2010
Chen Xiaoli, Guo Jin, Lei Yunping, Zou Jizhen, Lu Xiaolin, Bao Yihua, Wu Lihua, Wu Jianxin, Zheng Xiaoying, Shen Yiping, Wu Bai-Lin, Zhang Ting
Abstract excerpt
BACKGROUND: Neural tube defects are severe, common birth defects that result from failure of neural tube closure. They are considered to be a multifactorial disorder, and our knowledge of causal mechanisms remains limited. We hypothesized that abnormal DNA methylation occurs in NTD-affected fetuses. The correlations of global DNA methylation levels with complexity of NTDs and known risk factors of NTDs, MTHFR...
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