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Article

Ldb1 Is Essential for the Development of Isthmic Organizer and Midbrain Dopaminergic Neurons.

Stem cells and development - 1 Jul 2016

Kim Soojin, Zhao Yangu, Lee Ja-Myong, Kim Woon Ryoung, Gorivodsky Marat, Westphal Heiner, Geum Dongho

Abstract excerpt

LIM domain-binding protein 1 (Ldb1) is a nuclear cofactor that interacts with LIM homeodomain proteins to form multiprotein complexes that are important for transcription regulation. Ldb1 has been shown to play essential roles in various processes during mouse embryogenesis. To determine the role of Ldb1 in mid- and hindbrain development, we have generated a conditional mutant with a specific deletion of the Ldb1...

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Identifiers

PMID: 27171818
DOI: 10.1089/scd.2015.0307
PMCID: PMC4932781

Genes

FGF8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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