Article
Lmx1a and lmx1b function cooperatively to regulate proliferation, specification, and differentiation of midbrain dopaminergic progenitors.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 31 Aug 2011
Yan Carol H, Levesque Martin, Claxton Suzanne, Johnson Randy L, Ang Siew-Lan
Abstract excerpt
LIM homeodomain transcription factors, Lmx1a and Lmx1b, are required for the development of midbrain dopaminergic (mDA) neurons. Lmx1b is required for the specification and maintenance of mDA neurons, primarily due to its role in isthmic organizer development that is essential for the induction of mDA neurons. Here, we conditionally deleted Lmx1b in the ventral neural tube using ShhCre and found that Lmx1b...
Topics
- Animals
- Animals, Newborn
- Bromodeoxyuridine
- Cell Count
- Cell Cycle
- Cell Differentiation
- Cell Proliferation
- Dopamine
- Embryo, Mammalian
- Gene Expression Regulation, Developmental
- Hedgehog Proteins
- Homeodomain Proteins
- In Vitro Techniques