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Article

Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors.

Development (Cambridge, England) - 1 Jul 2012

Metzakopian Emmanouil, Lin Wei, Salmon-Divon Mali, Dvinge Heidi, Andersson Elisabet, Ericson Johan, Perlmann Thomas, Whitsett Jeffrey A, Bertone Paul, Ang Siew-Lan

Abstract excerpt

The transcription factors Foxa1 and Foxa2 promote the specification of midbrain dopaminergic (mDA) neurons and the floor plate. Whether their role is direct has remained unclear as they also regulate the expression of Shh, which has similar roles. We characterized the Foxa2 cis-regulatory network...

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Identifiers

PMID: 22696295
DOI: 10.1242/dev.081034
PMCID: PMC3383233

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22696295-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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