Article
Functional ablation of the mouse Ldb1 gene results in severe patterning defects during gastrulation.
Development (Cambridge, England) - 1 Feb 2003
Mukhopadhyay Mahua, Teufel Andreas, Yamashita Tsuyoshi, Agulnick Alan D, Chen Lan, Downs Karen M, Schindler Alice, Grinberg Alexander, Huang Sing-Ping, Dorward David, Westphal Heiner
Abstract excerpt
The LIM domain-binding protein 1 (Ldb1) is found in multi-protein complexes containing various combinations of LIM-homeodomain, LIM-only, bHLH, GATA and Otx transcription factors. These proteins exert key functions during embryogenesis. Here we show that targeted deletion of the Ldb1 gene in mice results in a pleiotropic phenotype. There is no heart anlage and head structures are truncated anterior to the...
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