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Article

An evolutionarily conserved Lhx2-Ldb1 interaction regulates the acquisition of hippocampal cell fate and regional identity.

Development (Cambridge, England) - 19 Oct 2020

Kinare Veena, Iyer Archana, Padmanabhan Hari, Godbole Geeta, Khan Tooba, Khatri Zeba, Maheshwari Upasana, Muralidharan Bhavana, Tole Shubha

Abstract excerpt

The protein co-factor Ldb1 regulates cell fate specification by interacting with LIM-homeodomain (LIM-HD) proteins in a tetrameric complex consisting of an LDB:LDB dimer that bridges two LIM-HD molecules, a mechanism first demonstrated in the Drosophila wing disc. Here, we demonstrate conservation of this interaction in the regulation of mammalian hippocampal development, which is profoundly defective upon loss...

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PMID: 32994168
DOI: 10.1242/dev.187856

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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