Article
Lmx1a is an activator of Rgs4 and Grb10 and is responsible for the correct specification of rostral and medial mdDA neurons.
The European journal of neuroscience - 1 Jan 2013
Hoekstra Elisa J, von Oerthel Lars, van der Linden Annemarie J A, Schellevis Raymond D, Scheppink Gerard, Holstege Frank C P, Groot-Koerkamp Marian J, van der Heide Lars P, Smidt Marten P
Abstract excerpt
The LIM homeodomain transcription factor Lmx1a is a very potent inducer of stem cells towards dopaminergic neurons. Despite several studies on the function of this gene, the exact in vivo role of Lmx1a in mesodiencephalic dopamine (mdDA) neuronal specification is still not understood. To analyse the genes functioning downstream of Lmx1a, we performed expression microarray analysis of LMX1A-overexpressing MN9D...
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