Article
Lmx1b is essential for Fgf8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in mice.
Development (Cambridge, England) - 1 Jan 2007
Guo Chao, Qiu Hai-Yan, Huang Ying, Chen Haixu, Yang Rong-Qiang, Chen Sheng-Di, Johnson Randy L, Chen Zhou-Feng, Ding Yu-Qiang
Abstract excerpt
Secreted factors FGF8 and WNT1 are essential either for the inductive activity of the isthmus organizer or for the regionalization of the midbrain-hindbrain boundary (MHB). However, transcriptional regulation of these secreted factors during development remains to be elucidated. Here we show that the LIM homeobox gene Lmx1b is expressed in the anterior embryo as early as E7.5 and its expression becomes...
Topics
- Animals
- Cerebellum
- Female
- Fibroblast Growth Factor 8
- Gene Expression Regulation, Developmental
- Homeodomain Proteins
- In Situ Hybridization
- LIM-Homeodomain Proteins
- Male
- Mice