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Article

Lmx1b is essential for Fgf8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in mice.

Development (Cambridge, England) - 1 Jan 2007

Guo Chao, Qiu Hai-Yan, Huang Ying, Chen Haixu, Yang Rong-Qiang, Chen Sheng-Di, Johnson Randy L, Chen Zhou-Feng, Ding Yu-Qiang

Abstract excerpt

Secreted factors FGF8 and WNT1 are essential either for the inductive activity of the isthmus organizer or for the regionalization of the midbrain-hindbrain boundary (MHB). However, transcriptional regulation of these secreted factors during development remains to be elucidated. Here we show that the LIM homeobox gene Lmx1b is expressed in the anterior embryo as early as E7.5 and its expression becomes...

Read the complete abstract on PubMed

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Share to Fibroblast Growth Factor 8

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

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Share to Mice, Mutant Strains

Share to Wnt1 Protein

Source

Identifiers

PMID: 17166916
DOI: 10.1242/dev.02745

Genes

FGF8
WNT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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