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Article

Polygenic Risk for Schizophrenia Influences Cortical Gyrification in 2 Independent General Populations

11 May 2016

Abstract excerpt

Schizophrenia is highly heritable, whereas the effect of each genetic variant is very weak. Since clinical heterogeneity and complexity of schizophrenia is high, considerable effort has been made to relate genetic variants to underlying neurobiological aspects of schizophrenia (endophenotypes). Given the polygenic nature of schizophrenia, our goal was to form a measure of additive genetic risk and explore its...

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PMID: 27169464
DOI: 10.1093/schbul/sbw051

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