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Article

Schizophrenia risk variants modulate white matter volume across the psychosis spectrum: evidence from two independent cohorts.

NeuroImage. Clinical - 1 Jan 2015

Oertel-Knöchel Viola, Lancaster Thomas M, Knöchel Christian, Stäblein Michael, Storchak Helena, Reinke Britta, Jurcoane Alina, Kniep Jonathan, Prvulovic David, Mantripragada Kiran, Tansey Katherine E, O'Donovan Michael C, Owen Michael J, Linden David E J

Abstract excerpt

Polygenic risk scores, based on risk variants identified in genome-wide-association-studies (GWAS), explain a considerable portion of the heritability for schizophrenia (SZ) and bipolar disorder (BD). However, little is known about the combined effects of these variants, although polygenic neuroimaging has developed into a powerful tool of translational neuroscience. In this study, we used genome wide significant...

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Identifiers

PMID: 25844328
DOI: 10.1016/j.nicl.2015.03.005
PMCID: PMC4375641

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