Article
Polygenic risk for schizophrenia, transition and cortical gyrification: a high-risk study.
Psychological medicine - 1 Jul 2018
Neilson E, Bois C, Clarke T-K, Hall L, Johnstone E C, Owens D G C, Whalley H C, McIntosh A M, Lawrie S M
Abstract excerpt
BACKGROUND: Schizophrenia is a highly heritable disorder, linked to several structural abnormalities of the brain. More specifically, previous findings have suggested that increased gyrification in frontal and temporal regions are implicated in the pathogenesis of schizophrenia. METHODS: The current study included participants at high familial risk of schizophrenia who remained well (n = 31), who developed...
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