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Polygenic contributions to brain cortical measures, subcortical volumes and hippocampal subfields in first episode psychosis.

Progress in neuro-psychopharmacology & biological psychiatry - 2 Apr 2026

Segura Alex G, Masias Mireia, Julià Laura, García-Rizo Clemente, Forte Maria Florencia, Trabsa Amira, Cuesta Manuel J, Vieta Eduard, Castro-Fornieles Josefina, Amoretti Silvia, Mas Sergi, Valli Isabel

Abstract excerpt

BACKGROUND: Psychosis is characterized by both genetic and neurostructural abnormalities. However, the mechanisms linking genetic risk to brain structural alterations remain unclear. This study investigates associations between polygenic risk scores (PRS) and brain structural measures in individuals experiencing a first-episode psychosis (FEP) and healthy controls (HC). METHODS: A total of 241 participants (130...

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PMID: 41881418
DOI: 10.1016/j.pnpbp.2026.111675

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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