Article
Partitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia.
Molecular psychiatry - 1 Dec 2016
Lee P H, Baker J T, Holmes A J, Jahanshad N, Ge T, Jung J-Y, Cruz Y, Manoach D S, Hibar D P, Faskowitz J, McMahon K L, de Zubicaray G I, Martin N G, Wright M J, Öngür D, Buckner R, Roffman J, Thompson P M, Smoller J W
Abstract excerpt
Schizophrenia is a devastating neurodevelopmental disorder with a complex genetic etiology. Widespread cortical gray matter loss has been observed in patients and prodromal samples. However, it remains unresolved whether schizophrenia-associated cortical structure variations arise due to disease etiology or secondary to the illness. Here we address this question using a partitioning-based heritability analysis of...
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