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In vitro metabolism of phenytoin in 36 CYP2C9 variants found in the Chinese population.

Chemico-biological interactions - 25 Jun 2016

Chen Lian-Guo, Wang Zhe, Zhu Yuan, Xiong Jian-Hua, Sun Li-Rong, Dai Da-Peng, Cai Jian-Ping, Hu Guo-Xin

Abstract excerpt

Cytochrome P450 2C9 (CYP2C9) is an important member of the cytochrome P450 enzyme superfamily, with 57 CYP2C9 allelic variants being previously reported. Recently, we identified 22 novel alleles (*36 -*56 and N418T) in the Han Chinese population. This study aims to assess the catalytic activities of wild-type (CYP2C9*1) and 36 CYP2C9 allelic variants found in the Chinese population toward phenytoin (PHT)...

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Identifiers

PMID: 27163851
DOI: 10.1016/j.cbi.2016.04.040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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