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Article

Effect of Cytochrome P450 2C9 genetic polymorphism on agomelatine metabolism in vitro.

PeerJ - 1 Jan 2026

Fang Ping, Ni Jinhuan, Shen Taoye, Chen Qing, Ye Xinwu, Jin Jia, Dai Dapeng, Hu Guoxin, Qian Jianchang, Cai Jianping, Chen Lianguo

Abstract excerpt

Background: Genetic polymorphisms of CYP2C9 significantly influence the efficacy and safety of some drugs, which potentially lead to adverse effects and therapeutic failure. The aim of this study was to investigate the genetic polymorphism of 37 CYP2C9 alleles and evaluate their catalytic activities in agomelatine metabolism in vitro. Methods: Insect microsomes expressing the 37 recombinant CYP2C9 variants were...

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Identifiers

PMID: 41873427
DOI: 10.7717/peerj.20973
PMCID: PMC13006006

Genes

CYP2C9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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