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Article

CYP2C9 polymorphisms and phenytoin metabolism: implications for adverse effects.

Expert opinion on drug metabolism & toxicology - 1 Jan 2015

Franco Valentina, Perucca Emilio

Abstract excerpt

INTRODUCTION: Phenytoin, a widely prescribed old-generation antiepileptic drug, requires careful individualization of dosage to compensate for its prominent pharmacokinetic variability. This article reviews the contribution of genetic polymorphisms affecting the activity of CYP2C9, the main enzyme responsible for phenytoin metabolism, to the variation in phenytoin clearance and susceptibility to adverse effects....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26037375
DOI: 10.1517/17425255.2015.1053463

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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