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Article

Effect of CYP2C polymorphisms on the pharmacokinetics of phenytoin in Japanese patients with epilepsy.

Biological & pharmaceutical bulletin - 1 Aug 1996

Hashimoto Y, Otsuki Y, Odani A, Takano M, Hattori H, Furusho K, Iui K

Abstract excerpt

We examined the effect of CYP2C9/19 polymorphisms on the pharmacokinetics of phenytoin in 17 Japanese patients with epilepsy. The maximal elimination rate (Vmax) of phenytoin was slightly decreased (up to 14%) in patients with CYP2C19 mutations for the defective allele. The Vmax values in patient...

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Source

Identifiers

PMID: 8874828
DOI: 10.1248/bpb.19.1103

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-8874828-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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