Article
The clonal and mutational evolution spectrum of primary triple-negative breast cancers.
Nature - 4 Apr 2012
Shah Sohrab P, Roth Andrew, Goya Rodrigo, Oloumi Arusha, Ha Gavin, Zhao Yongjun, Turashvili Gulisa, Ding Jiarui, Tse Kane, Haffari Gholamreza, Bashashati Ali, Prentice Leah M, Khattra Jaswinder, Burleigh Angela, Yap Damian, Bernard Virginie, McPherson Andrew, Shumansky Karey, Crisan Anamaria, Giuliany Ryan, Heravi-Moussavi Alireza, Rosner Jamie, Lai Daniel, Birol Inanc, Varhol Richard, Tam Angela, Dhalla Noreen, Zeng Thomas, Ma Kevin, Chan Simon K, Griffith Malachi, Moradian Annie, Cheng S-W Grace, Morin Gregg B, Watson Peter, Gelmon Karen, Chia Stephen, Chin Suet-Feung, Curtis Christina, Rueda Oscar M, Pharoah Paul D, Damaraju Sambasivarao, Mackey John, Hoon Kelly, Harkins Timothy, Tadigotla Vasisht, Sigaroudinia Mahvash, Gascard Philippe, Tlsty Thea, Costello Joseph F, Meyer Irmtraud M, Eaves Connie J, Wasserman Wyeth W, Jones Steven, Huntsman David, Hirst Martin, Caldas Carlos, Marra Marco A, Aparicio Samuel
Abstract excerpt
Primary triple-negative breast cancers (TNBCs), a tumour type defined by lack of oestrogen receptor, progesterone receptor and ERBB2 gene amplification, represent approximately 16% of all breast cancers. Here we show in 104 TNBC cases that at the time of diagnosis these cancers exhibit a wide and continuous spectrum of genomic evolution, with some having only a handful of coding somatic aberrations in a few...
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