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Article

Clinical and molecular relevance of mutant-allele tumor heterogeneity in breast cancer.

Breast cancer research and treatment - 1 Feb 2017

Ma Ding, Jiang Yi-Zhou, Liu Xi-Yu, Liu Yi-Rong, Shao Zhi-Ming

Abstract excerpt

PURPOSE: Intra-tumor heterogeneity (ITH) plays a pivotal role in driving breast cancer progression and therapeutic resistance. We used a mutant-allele tumor heterogeneity (MATH) algorithm to measure ITH and explored its correlation with clinical parameters and multi-omics data. METHODS: We assessed 916 female breast cancer patients from The Cancer Genome Atlas. We calculated the MATH values from whole-exome...

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Source

Identifiers

PMID: 28093659
DOI: 10.1007/s10549-017-4113-z

Genes

MYC
CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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