Article
Somatic mutations and copy number variations in breast cancers with heterogeneous HER2 amplification.
Molecular oncology - 1 Apr 2020
Van Bockstal Mieke R, Agahozo Marie Colombe, van Marion Ronald, Atmodimedjo Peggy N, Sleddens Hein F B M, Dinjens Winand N M, Visser Lindy L, Lips Esther H, Wesseling Jelle, van Deurzen Carolien H M
Abstract excerpt
Intratumour heterogeneity fuels carcinogenesis and allows circumventing specific targeted therapies. HER2 gene amplification is associated with poor outcome in invasive breast cancer. Heterogeneous HER2 amplification has been described in 5-41% of breast cancers. Here, we investigated the genetic differences between HER2-positive and HER2-negative admixed breast cancer components. We performed an in-depth...
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