Article
Profiling the Somatic Mutational Landscape of Breast Tumors from Hispanic/Latina Women Reveals Conserved and Unique Characteristics.
Cancer research - 1 Aug 2023
Ding Yuan Chun, Song Hanbing, Adamson Aaron W, Schmolze Daniel, Hu Donglei, Huntsman Scott, Steele Linda, Patrick Carmina S, Tao Shu, Hernandez Natalie, Adams Charleen D, Fejerman Laura, Gardner Kevin, Nápoles Anna María, Pérez-Stable Eliseo J, Weitzel Jeffrey N, Bengtsson Henrik, Huang Franklin W, Neuhausen Susan L, Ziv Elad
Abstract excerpt
Somatic mutational profiling is increasingly being used to identify potential targets for breast cancer. However, limited tumor-sequencing data from Hispanic/Latinas (H/L) are available to guide treatment. To address this gap, we performed whole-exome sequencing (WES) and RNA sequencing on 146 tumors and WES of matched germline DNA from 140 H/L women in California. Tumor intrinsic subtype, somatic mutations,...
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