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The mutational landscape of a US Midwestern breast cancer cohort reveals subtype-specific cancer drivers and prognostic markers.

Human genomics - 15 Jul 2023

Vellichirammal Neetha Nanoth, Tan Yuan-De, Xiao Peng, Eudy James, Shats Oleg, Kelly David, Desler Michelle, Cowan Kenneth, Guda Chittibabu

Abstract excerpt

BACKGROUND: Female breast cancer remains the second leading cause of cancer-related death in the USA. The heterogeneity in the tumor morphology across the cohort and within patients can lead to unpredictable therapy resistance, metastasis, and clinical outcome. Hence, supplementing classic pathological markers with intrinsic tumor molecular markers can help identify novel molecular subtypes and the discovery of...

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Identifiers

PMID: 37454130
DOI: 10.1186/s40246-023-00511-6
PMCID: PMC10349437

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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