Article
Deciphering and Targeting Oncogenic Mutations and Pathways in Breast Cancer.
The oncologist - 1 Sept 2016
Santarpia Libero, Bottai Giulia, Kelly Catherine M, Győrffy Balázs, Székely Borbala, Pusztai Lajos
Abstract excerpt
UNLABELLED: : Advances in DNA and RNA sequencing revealed substantially greater genomic complexity in breast cancer than simple models of a few driver mutations would suggest. Only very few, recurrent mutations or copy-number variations in cancer-causing genes have been identified. The two most common alterations in breast cancer are TP53 (affecting the majority of triple-negative breast cancers) and PIK3CA...
Topics
- Biomarkers, Tumor
- DNA Copy Number Variations
- Female
- Genetic Predisposition to Disease
- Genomics
- High-Throughput Nucleotide Sequencing
- Humans
- Molecular Targeted Therapy
- Mutation
- Receptor, ErbB-2
- Triple Negative Breast Neoplasms