Article
Association of mitochondrial displacement loop polymorphisms with risk of colorectal cancer in south Indian population.
Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis - 1 Sept 2017
Govatati Suresh, Saradamma Bulle, Malempati Sravanthi, Dasi Divyamaanasa, Thupurani Murali Krishna, Nagesh Narayana, Shivaji Sisinthy, Bhanoori Manjula, Tamanam Raghava Rao, Nallanchakravarthula Varadacharyulu, Pasupuleti Sreenivasa Rao
Abstract excerpt
Mitochondrial displacement loop (D-loop) is the hot spot for mitochondrial DNA (mtDNA) alterations which influence the generation of cellular reactive oxygen species. In the present study, we sequenced the entire mitochondrial D-loop region (1124 bp) of colorectal cancer (CRC) patients (n = 174) and controls (n = 170) of south Indian origin to identify significant mutations/polymorphisms. Our results showed 152...
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