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Manganese-superoxide dismutase (Mn-SOD) overexpression is a common event in colorectal cancers with mitochondrial microsatellite instability.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Aug 2016

Govatati Suresh, Malempati Sravanthi, Saradamma Bulle, Divyamaanasa Dasi, Naidu B Prathap, Bramhachari Pallaval Veera, Narayana Nagesh, Shivaji Sisinthy, Bhanoori Manjula, Tamanam Raghava Rao, Rao Pasupuleti Sreenivasa, Nallanchakravarthula Varadacharyulu

Abstract excerpt

Mitochondrial displacement loop (D-loop) is a hot spot for mitochondrial DNA (mtDNA) alterations that effects cellular reactive oxygen species (ROS) generation. Manganese-superoxide dismutase (Mn-SOD) is a major antioxidant enzyme that protects cells from ROS-mediated damage. In the present study, we investigated the relationship between sequence alterations of mitochondrial D-loop and Mn-SOD expression in...

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PMID: 26846100
DOI: 10.1007/s13277-016-4918-0

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