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Single nucleotide polymorphisms in the D-loop region of mitochondrial DNA is associated with colorectal cancer outcome.

Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis - 1 Nov 2016

Wang Cuiju, Zhao Shengnan, Du Yanming, Guo Zhanjun

Abstract excerpt

Single nucleotide polymorphisms (SNPs) in the displacement loop (D-Loop) of mitochondrial DNA (mtDNA) has been identified for their association with the risk and outcome in many cancers. We have identified risk associated D-loop SNPs for colorectal cancer previously, in the present study, we evaluate their prognostic value for postoperative survival of colorectal cancer (CRC). The minor haplotype of nucleotides...

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PMID: 26545175
DOI: 10.3109/19401736.2015.1089502

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