Article
Association of sequence polymorphism in the mitochondrial D-loop with chronic kidney disease.
Renal failure - 1 Jun 2014
Bai Yaling, Guo Zhanjun, Xu Jinsheng, Zhang Junxia, Cui Liwen, Zhang Huiran, Zhang Shenglei, Ai Xiaolu
Abstract excerpt
BACKGROUND: The mitochondrial displacement loop (D-loop) is known to accumulate mutations and single nucleotide polymorphisms (SNPs) at a higher frequency than other regions of mitochondrial DNA (mtDNA). METHODS: This is a case-control study. We sequenced SNPs in the D-loop of mtDNA and investigated their association with the risk of chronic kidney disease (CKD). RESULTS: A total of 144 SNPs referring to the...
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