Article
Systematic Functional Interrogation of Rare Cancer Variants Identifies Oncogenic Alleles.
Cancer discovery - 1 Jul 2016
Kim Eejung, Ilic Nina, Shrestha Yashaswi, Zou Lihua, Kamburov Atanas, Zhu Cong, Yang Xiaoping, Lubonja Rakela, Tran Nancy, Nguyen Cindy, Lawrence Michael S, Piccioni Federica, Bagul Mukta, Doench John G, Chouinard Candace R, Wu Xiaoyun, Hogstrom Larson, Natoli Ted, Tamayo Pablo, Horn Heiko, Corsello Steven M, Lage Kasper, Root David E, Subramanian Aravind, Golub Todd R, Getz Gad, Boehm Jesse S, Hahn William C
Abstract excerpt
UNLABELLED: Cancer genome characterization efforts now provide an initial view of the somatic alterations in primary tumors. However, most point mutations occur at low frequency, and the function of these alleles remains undefined. We have developed a scalable systematic approach to interrogate the function of cancer-associated gene variants. We subjected 474 mutant alleles curated from 5,338 tumors to pooled in...
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