Pervasive tissue specificity of driver genes revealed by mutational analysis of 265 cancer types

Abstract excerpt

Defining genes that are somatically mutated in different cancer types is a central goal of cancer genetics. Nevertheless, traditional definitions of "driver" genes are biased toward common cancer types and tend to overlook genes that might be specific to rarer subtypes. We developed a statistical framework that defines genes enriched for functional somatic mutations in primary cancers to quantify incidence and tis...

Topics

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• Bioinformatics and Genomic Networks
• Cancer Genomics and Diagnostics
• Genetic factors in colorectal cancer

Identifiers and source

Literature Corpus work

71e594c6-ce24-5ea4-96ed-fb23d329e761

DOI

10.1016/j.isci.2026.117272