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Article

Functional Analysis of Rare RAS Variants of Unknown Significance.

Cancer research communications - 1 Oct 2025

Park Soohwan, Ikegami Masachika, Kitada Rina, Takamochi Kazuya, Suzuki Kenji, Mano Hiroyuki, Kohsaka Shinji

Abstract excerpt

The RAS gene is frequently mutated in human cancers. Whereas the functional significance of frequent mutations is well established, the significance of rare mutations remains unknown. This study aimed to comprehensively investigate the function of rare RAS variants and provide new insights about their clinical relevance. A total of 298 K/N/HRAS variants (169, 72, and 57 variants, respectively) reported in the...

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Source

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Identifiers

PMID: 40970755
DOI: 10.1158/2767-9764.CRC-25-0188
PMCID: PMC12488390

Genes

KRAS
HRAS
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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