Article
Systematic Functional Annotation of Somatic Mutations in Cancer.
Cancer cell - 12 Mar 2018
Ng Patrick Kwok-Shing, Li Jun, Jeong Kang Jin, Shao Shan, Chen Hu, Tsang Yiu Huen, Sengupta Sohini, Wang Zixing, Bhavana Venkata Hemanjani, Tran Richard, Soewito Stephanie, Minussi Darlan Conterno, Moreno Daniela, Kong Kathleen, Dogruluk Turgut, Lu Hengyu, Gao Jianjiong, Tokheim Collin, Zhou Daniel Cui, Johnson Amber M, Zeng Jia, Ip Carman Ka Man, Ju Zhenlin, Wester Matthew, Yu Shuangxing, Li Yongsheng, Vellano Christopher P, Schultz Nikolaus, Karchin Rachel, Ding Li, Lu Yiling, Cheung Lydia Wai Ting, Chen Ken, Shaw Kenna R, Meric-Bernstam Funda, Scott Kenneth L, Yi Song, Sahni Nidhi, Liang Han, Mills Gordon B
Abstract excerpt
The functional impact of the vast majority of cancer somatic mutations remains unknown, representing a critical knowledge gap for implementing precision oncology. Here, we report the development of a moderate-throughput functional genomic platform consisting of efficient mutant generation, sensitive viability assays using two growth factor-dependent cell models, and functional proteomic profiling of signaling...
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