Article

Distinct mutational landscapes when comparing germline and somatic cancer variants in forty tumor suppressor genes

2026-02-28

Abstract excerpt

Germline and somatic cancer variants in tumor suppressor genes (TSGs) share loss of function mechanisms with studies of a few genes ( DICER1 , CEBPA ) highlighting differences in variant consequence and location. To systematically assess whether TSGs display distinct mutational patterns we leveraged large public genetic databases and compared high-quality pathogenic/likely pathogenic (P/LP) germline variants in...

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Literature Corpus work: 0c5e1300-389e-5faf-8923-eaf761baa72f
DOI: 10.64898/2026.02.26.707048

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