Article
Beyond histology: translating tumor genotypes into clinically effective targeted therapies.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2014
Meador Catherine B, Micheel Christine M, Levy Mia A, Lovly Christine M, Horn Leora, Warner Jeremy L, Johnson Douglas B, Zhao Zhongming, Anderson Ingrid A, Sosman Jeffrey A, Vnencak-Jones Cindy L, Dahlman Kimberly B, Pao William
Abstract excerpt
Increased understanding of intertumoral heterogeneity at the genomic level has led to significant advancements in the treatment of solid tumors. Functional genomic alterations conferring sensitivity to targeted therapies can take many forms, and appropriate methods and tools are needed to detect these alterations. This review provides an update on genetic variability among solid tumors of similar histologic...
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