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Article

The origins and genetic interactions of KRAS mutations are allele- and tissue-specific.

Nature communications - 22 Mar 2021

Cook Joshua H, Melloni Giorgio E M, Gulhan Doga C, Park Peter J, Haigis Kevin M

Abstract excerpt

Mutational activation of KRAS promotes the initiation and progression of cancers, especially in the colorectum, pancreas, lung, and blood plasma, with varying prevalence of specific activating missense mutations. Although epidemiological studies connect specific alleles to clinical outcomes, the mechanisms underlying the distinct clinical characteristics of mutant KRAS alleles are unclear. Here, we analyze 13,492...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33753749
DOI: 10.1038/s41467-021-22125-z
PMCID: PMC7985210

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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