Article
Accelerating Discovery of Functional Mutant Alleles in Cancer.
Cancer discovery - 1 Feb 2018
Chang Matthew T, Bhattarai Tripti Shrestha, Schram Alison M, Bielski Craig M, Donoghue Mark T A, Jonsson Philip, Chakravarty Debyani, Phillips Sarah, Kandoth Cyriac, Penson Alexander, Gorelick Alexander, Shamu Tambudzai, Patel Swati, Harris Christopher, Gao JianJiong, Sumer Selcuk Onur, Kundra Ritika, Razavi Pedram, Li Bob T, Reales Dalicia N, Socci Nicholas D, Jayakumaran Gowtham, Zehir Ahmet, Benayed Ryma, Arcila Maria E, Chandarlapaty Sarat, Ladanyi Marc, Schultz Nikolaus, Baselga José, Berger Michael F, Rosen Neal, Solit David B, Hyman David M, Taylor Barry S
Abstract excerpt
Most mutations in cancer are rare, which complicates the identification of therapeutically significant mutations and thus limits the clinical impact of genomic profiling in patients with cancer. Here, we analyzed 24,592 cancers including 10,336 prospectively sequenced patients with advanced disease to identify mutant residues arising more frequently than expected in the absence of selection. We identified 1,165...
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