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Article

HUWE1 interacts with PCNA to alleviate replication stress.

EMBO reports - 1 Jun 2016

Choe Katherine N, Nicolae Claudia M, Constantin Daniel, Imamura Kawasawa Yuka, Delgado-Diaz Maria Rocio, De Subhajyoti, Freire Raimundo, Smits Veronique Aj, Moldovan George-Lucian

Abstract excerpt

Defects in DNA replication, DNA damage response, and DNA repair compromise genomic stability and promote cancer development. In particular, unrepaired DNA lesions can arrest the progression of the DNA replication machinery during S-phase, causing replication stress, mutations, and DNA breaks. HUWE1 is a HECT-type ubiquitin ligase that targets proteins involved in cell fate, survival, and differentiation. Here, we...

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Source

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Identifiers

PMID: 27146073
DOI: 10.15252/embr.201541685
PMCID: PMC5278616

Genes

HUWE1
PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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