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BAP1 promotes stalled fork restart and cell survival via INO80 in response to replication stress

14 Oct 2019

Abstract excerpt

The recovery from replication stress by restarting stalled forks to continue DNA synthesis is crucial for maintaining genome stability and thereby preventing diseases such as cancer. We previously showed that BRCA1-associated protein 1 (BAP1), a nuclear deubiquitinase with tumor suppressor activity, promotes replication fork progression by stabilizing the INO80 chromatin remodeler via deubiquitination and...

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PMID: 31657441
DOI: 10.1042/bcj20190622

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BAP1 promotes stalled fork restart and cell survival via INO80 in response to replication stressPMID 31657441Read ↗

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Ino80 chromatin remodeling complex promotes recovery of stalled replication forks.Semantic proximity Read ↗

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CHAF1A promotes the translesion DNA synthesis pathway in response to DNA replication stressSemantic proximity Read ↗

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